Students are provided a wide range of opportunities for prayer and worship. Each month the school celebrates Mass together as an entire community and additionally each class attends Mass with the Felician Sisters once a month. The Chapel is open to students at any time for personal prayer and reflection. OLSH's Chaplain celebrates most school Masses and also visits campus regularly for confessions and fellowship with students. On occasion, other priests come to celebrate Mass or lead prayer services throughout the year.
Each September the OLSH community hosts adoration of the Blessed Sacrament followed by a Eucharistic Procession to commemorate the start of the school year and to celebrate the Eucharist. The bells toll from the chapel bell tower as the procession winds throughout the entire OLSH campus. Art students create sidewalk drawings throughout campus to enhance the celebration. The OLSH Chaplain carries the Blessed Sacrament in a procession led by a color guard of OLSH students and the Knights of Columbus, followed in procession by the entire student body. The culmination of the celebration is benediction at the statue of Our Lady of the Sacred Heart.